"Madonna and Child with Saint Jerome, Saint Bernardino, and Angels" by Sano di Pietro is a notable 15th-century Italian painting that exemplifies the artist's delicate and devotional style. This artwork features the Virgin Mary holding the Christ Child, surrounded by two saints—Saint Jerome and Saint Bernardino of Siena—and a host of angels. Sano di Pietro's use of rich colors, intricate details, and gold leaf highlights the sanctity of the figures and the heavenly atmosphere. The composition is balanced and harmonious, with each saint depicted in a contemplative pose, adding to the painting's serene and reverent tone. This work reflects the deep religious fervor of the period and Sano di Pietro's skill in conveying spiritual themes through art.